Signal recognition particle subunit SRP72 (SRP72) is a 671-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O76094.
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The mean pLDDT of this model is 81.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68…
Heterodimer with SRP68 (PubMed:16672232, PubMed:27899666, PubMed:28369529). SRP68-SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Within the SRP complex,…
Cytoplasm, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5M72 | X-ray | 1.6 Å | A=10-166 |
| 5WRV | X-ray | 1.7 Å | B=1-163 |
| 8QVX | EM | 2.7 Å | B=1-671 |
| 5WRW | X-ray | 2.91 Å | A/B/C/D/E/F=1-163 |
| 8QVW | EM | 3.0 Å | B=1-671 |
| 7NFX | EM | 3.2 Å | z=1-671 |
| 5M73 | X-ray | 3.4 Å | D/H=512-668 |
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