YEATS domain-containing protein 4 (YEATS4) is a 227-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O95619.
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The mean pLDDT of this model is 91.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:29900004, PubMed:30071723). Also able to recognize and bind crotonylated histone H3 (PubMed:30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidence is…
Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity (PubMed:12963728, PubMed:14966270). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8IJ0 | X-ray | 1.52 Å | A/B=19-159 |
| 7EIF | X-ray | 1.58 Å | A=19-159 |
| 5R68 | X-ray | 1.64 Å | A/B=18-190 |
| 9X8S | X-ray | 1.7 Å | A/B/C/D=15-146 |
| 5R69 | X-ray | 1.83 Å | A/B=18-190 |
| 5VNA | X-ray | 2.1 Å | A/B/C/D=1-148 |
| 5XTZ | X-ray | 2.1 Å | A/B/C/D=15-159 |
| 7JFY | X-ray | 2.1 Å | A/B/C/D=1-148 |
| 8IIZ | X-ray | 2.1 Å | A=19-159 |
| 8IIY | X-ray | 2.15 Å | A=19-159 |
| 8I60 | X-ray | 2.3 Å | C/D=11-150 |
| 9O4Y | X-ray | 2.3 Å | A/B/C/D=1-148 |
| 5VNB | X-ray | 2.4 Å | A/B/C/D=1-148 |
| 8DKB | X-ray | 2.58 Å | A/B/C/D/E/F/G/H=1-149 |
| 5Y8V | X-ray | 2.61 Å | A/B/C/D=21-160 |
| 9X8U | X-ray | 3.0 Å | A/B/C/D=15-145 |
| 8X15 | EM | 3.2 Å | W=1-227 |
| 8X19 | EM | 3.2 Å | W=1-227 |
| 8X1C | EM | 3.2 Å | W=1-227 |
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