P01008: Antithrombin-III (SERPINC1)

Antithrombin-III (SERPINC1) is a 464-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01008.

Gene: SERPINC1
Organism: Homo sapiens
Length: 464 residues
Mean pLDDT: 84.7
Model: AF-P01008-F1 v6
Model created: 1 Aug 2025
PDB structures: 27

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Model confidence (pLDDT)

The mean pLDDT of this model is 84.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	69%
70 to 90	Confident: backbone generally right	15%
50 to 70	Low: treat with caution	4%
Below 50	Very low: often disordered regions	12%

What pLDDT means and how to read it

Function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin

Subunit structure

Forms protease inhibiting heterodimer with TMPRSS7

Subcellular location

Secreted, extracellular space

Disease associations

Antithrombin III deficiency (AT3D)

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
3KCG	X-ray	1.7 Å	I=33-464
2B5T	X-ray	2.1 Å	I=33-464
1TB6	X-ray	2.5 Å	I=33-464
1E04	X-ray	2.6 Å	I/L=33-464
1JVQ	X-ray	2.6 Å	I/L=33-464
1NQ9	X-ray	2.6 Å	I/L=33-464
2ANT	X-ray	2.6 Å	I/L=33-464
1E05	X-ray	2.62 Å	I/L=33-464
1OYH	X-ray	2.62 Å	I/L=33-464
1R1L	X-ray	2.7 Å	I/L=33-464
2BEH	X-ray	2.7 Å	I/L=33-464
1T1F	X-ray	2.75 Å	A/B/C=33-464
1DZG	X-ray	2.8 Å	I/L=33-464
1LK6	X-ray	2.8 Å	I/L=33-464
2B4X	X-ray	2.8 Å	I/L=37-463
2ZNH	X-ray	2.8 Å	A/B=33-464
4EB1	X-ray	2.8 Å	I/L=33-464
1DZH	X-ray	2.85 Å	I/L=33-464
1AZX	X-ray	2.9 Å	I/L=33-464
1BR8	X-ray	2.9 Å	I/L=33-464

Showing 20 of 27 experimental structures (best resolution first).

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