Protransforming growth factor alpha (TGFA) is a 160-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01135.
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The mean pLDDT of this model is 66.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar
Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2
Secreted, extracellular space, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3E50 | X-ray | 2.3 Å | C/D=40-89 |
| 1MOX | X-ray | 2.5 Å | C/D=40-89 |
| 5KN5 | X-ray | 2.8 Å | C/F=49-88 |
| 7SZ7 | EM | 3.4 Å | C/D=40-89 |
| 7SZ5 | EM | 3.6 Å | C/D=40-89 |
| 1GK5 | NMR | A=83-89 | |
| 1YUF | NMR | A=40-89 | |
| 1YUG | NMR | A=40-89 | |
| 2TGF | NMR | A=40-89 | |
| 3TGF | NMR | A=40-89 | |
| 4TGF | NMR | A=40-89 |
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