Somatotropin (GH1) is a 217-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01241.
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The mean pLDDT of this model is 79.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6QIO | X-ray | 1.95 Å | D=27-217 |
| 1HUW | X-ray | 2.0 Å | A=27-217 |
| 1AXI | X-ray | 2.1 Å | A=27-217 |
| 1HGU | X-ray | 2.5 Å | A=27-217 |
| 1HWG | X-ray | 2.5 Å | A=27-217 |
| 1A22 | X-ray | 2.6 Å | A=27-217 |
| 1KF9 | X-ray | 2.6 Å | A/D=27-217 |
| 3HHR | X-ray | 2.8 Å | A=27-216 |
| 1BP3 | X-ray | 2.9 Å | A=27-217 |
| 1HWH | X-ray | 2.9 Å | A=27-217 |
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