1HWH: Growth hormone

1:1 complex of human growth hormone mutant G120R with its soluble binding protein. Determined by X-ray diffraction at 2.9 Å resolution. Released 19 Nov 1997.

Method: X-ray diffraction
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,034
Mol. weight: 49.53 kDa
Released: 19 Nov 1997

Explore 1HWH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1HWH contains 15 α-helices and 16 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	9-35	27
α-helix	38-46	9
α-helix	48-51	4
α-helix	54-56	3
α-helix	64-67	4
α-helix	72-85	14
α-helix	90-97	8
α-helix	107-127	21
α-helix	137-140	4
α-helix	156-182	27

Chain B: 5 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	35-39	5	1
β-strand	40	1	2
β-strand	46-50	5	1
β-strand	65-70	6	3
β-strand	81-82	2	3
α-helix	83	1
β-strand	93-96	4	1
α-helix	98-100	3
β-strand	106-112	7	3
β-strand	119-124	6	3
α-helix	125-128	4
β-strand	129	1	2
α-helix	131-134	4
β-strand	135-143	9	4
β-strand	150-158	9	4
β-strand	172-180	9	5
α-helix	185-186	2
β-strand	187-188	2	5
β-strand	196-203	8	4
β-strand	208-216	9	5
β-strand	229-231	3	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Growth hormone	A	protein	191	Homo sapiens	P01241 (AlphaFold model)
Growth hormone binding protein	B	protein	237	Homo sapiens	P10912 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1HWH_1 GROWTH HORMONE (chains A)
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPT
PSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEER
IQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIV
QCRSVEGSCGF

Sequence of entity 2 (B), FASTA

>1HWH_2 GROWTH HORMONE BINDING PROTEIN (chains B)
FSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKN
LGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDE
KCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKE
VNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMS

Primary citation

Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. Sundstrom, M., Lundqvist, T., Rodin, J. et al. J Biol Chem (1996) 271:32197-32203. DOI 10.1074/jbc.271.50.32197 · PubMed

Other PDB entries of the same protein (UniProt P01241 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1HUW 2.0 Å, The crystal structure of affinity-matured human growth hormone at 2 Å resolution
1AXI 2.1 Å, Structural plasticity at the hgh:hghbp interface
1HGU 2.5 Å, Human growth hormone
1HWG 2.5 Å, 1:2 complex of human growth hormone with its soluble binding protein
1A22 2.6 Å, Human growth hormone bound to single receptor
1KF9 2.6 Å, Phage display derived variant of human growth hormone complexed with two copies of the…
3HHR 2.8 Å, Human growth hormone and extracellular domain of its receptor: crystal structure of the…
1BP3 2.9 Å, The xray structure of a growth hormone-prolactin receptor complex

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