Pro-glucagon (GCG) is a 180-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01275.
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The mean pLDDT of this model is 68.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 46% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Binds to and activates the glucagon receptor GCGR, which couples to the G(s) G protein and elevates intracellular cAMP, triggering downstream metabolic responses (PubMed:32193322)
Interacts with GCGR
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6PHI | X-ray | 1.1 Å | A=53-81 |
| 6PHK | X-ray | 1.18 Å | A=53-81 |
| 8ANK | X-ray | 1.3 Å | A=118-123 |
| 6PHO | X-ray | 1.42 Å | A=53-81 |
| 6PHL | X-ray | 1.44 Å | A=53-81 |
| 8ANJ | X-ray | 1.55 Å | A=166-171 |
| 6PHP | X-ray | 1.65 Å | A=53-81 |
| 4ZGM | X-ray | 1.8 Å | B=98-128 |
| 5OTU | X-ray | 1.8 Å | B/D=98-128 |
| 6PHJ | X-ray | 1.99 Å | A=53-81 |
| 5OTV | X-ray | 2.0 Å | B/D=98-128 |
| 5OTX | X-ray | 2.0 Å | B/D=98-128 |
| 3IOL | X-ray | 2.1 Å | B=98-128 |
| 5OTW | X-ray | 2.1 Å | B/D=98-128 |
| 6X18 | EM | 2.1 Å | P=98-127 |
| 9N0E | EM | 2.3 Å | P=53-89 |
| 2G49 | X-ray | 2.5 Å | C/D=53-81 |
| 7DUQ | EM | 2.5 Å | P=98-127 |
| 7KI0 | EM | 2.5 Å | P=98-128 |
| 7KI1 | EM | 2.5 Å | P=98-127 |
Showing 20 of 42 experimental structures (best resolution first).
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