6PHK: Glucagon
Crystal structure of glucagon analog with mono-stereoinversion at position 21 (D-Asp21) in space group I41 at 1.18 A resolution. Determined by X-ray diffraction at 1.18 Å resolution. Released 1 Jul 2020.
- Method
- X-ray diffraction
- Resolution
- 1.18 Å
- Organism
- Homo sapiens
- Chains
- 1
- Atoms
- 291
- Mol. weight
- 3.49 kDa
- Released
- 1 Jul 2020
Explore 6PHK in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6PHK contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-27 | 23 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Glucagon | A | protein | 29 | Homo sapiens | P01275 (AlphaFold model) |
Sequence of entity 1 (A), FASTA
>6PHK_1 Glucagon (chains A)
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Primary citation
High resolution X-ray structure of glucagon and selected stereo-inversed analogs in novel crystallographic packing arrangement. Mroz, P.A., Gonzalez-Gutierrez, G., DiMarchi, R.D. To be published.
Other PDB entries of the same protein (UniProt P01275 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6PHI 1.1 Å, Crystal structure of native glucagon in space group I41 at 1.1 A resolution
- 8ANK 1.3 Å, Structure of the amyloid-forming peptide pEFIAWL from human GLP-1
- 6PHO 1.42 Å, Crystal structure of glucagon analog with selenomethionine substitutions at position 1…
- 6PHL 1.44 Å, Crystal structure of glucagon analog with mono-stereoinversion at position 23 (D-Val23)…
- 8ANJ 1.55 Å, Structure of the amyloid-forming peptide DFINWL from human GLP-2
- 6PHP 1.65 Å, Crystal structure of glucagon analog with 4-bromo-phenylalanine substitutions at…
- 4ZGM 1.8 Å, Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor…
- 5OTU 1.8 Å, Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Hcs
- 6PHJ 1.99 Å, Crystal structure of native glucagon in space group P213 at 1.99 A resolution
- 5OTV 2.0 Å, Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cyc/Thr11Hcs
- 5OTX 2.0 Å, Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cys/Thr11Cys
- 3IOL 2.1 Å, Crystal structure of Glucagon-Like Peptide-1 in complex with the extracellular domain of…
Browse structure collections
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