Interleukin-2 receptor subunit alpha (IL2RA) is a 272-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01589.
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The mean pLDDT of this model is 72.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6YIO | X-ray | 1.83 Å | B=22-213 |
| 2B5I | X-ray | 2.3 Å | D=22-238 |
| 1Z92 | X-ray | 2.8 Å | B=22-238 |
| 3NFP | X-ray | 2.86 Å | I/K=22-238 |
| 3IU3 | X-ray | 2.9 Å | I/J/K=22-238 |
| 9KMC | EM | 2.97 Å | A=22-240 |
| 2ERJ | X-ray | 3.0 Å | A/E=22-233 |
| 7F9W | EM | 3.2 Å | A=26-186 |
| 7ZMZ | X-ray | 3.2 Å | D=21-238 |
| 6VWU | X-ray | 3.4 Å | A=22-186 |
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