2ERJ: Heterotrimeric interleukin-2 receptor

Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2. Determined by X-ray diffraction at 3.0 Å resolution. Released 21 Feb 2006.

Method: X-ray diffraction
Resolution: 3.0 Å
Organism: Homo sapiens
Chains: 8
Atoms: 11,187
Mol. weight: 196.17 kDa
Ligands: NAG
Released: 21 Feb 2006

Explore 2ERJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2ERJ contains 45 α-helices and 106 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	7-10	4
β-strand	13-16	4	1
β-strand	20	1	2
β-strand	25-27	3	3
β-strand	34-36	3	4
α-helix	37	1
β-strand	43-45	3	3
β-strand	46-47	2	5
β-strand	54-55	2	5
β-strand	61-63	3	4
β-strand	104	1	2
α-helix	105-110	6
α-helix	117-118	2
β-strand	119-120	2	3
α-helix	121-122	2
β-strand	126-131	6	1
β-strand	136-139	4	6
β-strand	144-146	3	1
β-strand	147-149	3	7
β-strand	154-156	3	7
α-helix	157-159	3
β-strand	161-164	4	6

Chain B: 6 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	7-12	6	8
β-strand	17-23	7	8
β-strand	33-39	7	9
β-strand	46-49	4	9
β-strand	51-54	4	8
β-strand	57-63	7	8
β-strand	78-86	9	9
β-strand	89-98	10	9
α-helix	100-102	3
β-strand	104	1	8
α-helix	106-109	4
β-strand	110-117	8	10
β-strand	122-127	6	10
α-helix	133-135	3
β-strand	139-146	8	11
α-helix	152-154	3
β-strand	158-160	3	11
β-strand	166-169	4	10
α-helix	172-173	2
β-strand	177-186	10	11
α-helix	194-200	7
β-strand	201-204	4	11

Chain C: 4 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	39-43	5	12
β-strand	47-51	5	12
β-strand	64-69	6	13
β-strand	78-79	2	13
β-strand	83-85	3	12
β-strand	90-96	7	12
α-helix	97-99	3
β-strand	106-111	6	13
β-strand	119-124	6	13
α-helix	126-128	3
β-strand	130-131	2	12
α-helix	132-134	3
β-strand	136-142	7	14
β-strand	148-153	6	14
β-strand	161-168	8	15
β-strand	176-180	5	15
β-strand	185-188	4	14
β-strand	197-205	9	15
α-helix	214-221	8
β-strand	222-224	3	15

Chain D: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	4-28	25
α-helix	36-39	4
β-strand	44	1	16
β-strand	47	1	17
α-helix	53-56	4
α-helix	57-61	5
α-helix	63-73	11
α-helix	82-96	15
α-helix	104-106	3
β-strand	107	1	17
β-strand	112	1	16
α-helix	114-132	19

Chain E: 5 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	6-8	3
β-strand	13-16	4	18
β-strand	20	1	19
β-strand	25-27	3	20
β-strand	30	1	21
β-strand	34-36	3	22
α-helix	37	1
β-strand	43-45	3	20
β-strand	46-47	2	23
β-strand	54-55	2	23
β-strand	61-63	3	22
β-strand	104	1	19
α-helix	105-108	4
β-strand	113	1	21
β-strand	119-120	2	20
α-helix	121-122	2
β-strand	126-131	6	18
β-strand	136-139	4	24
β-strand	144-146	3	18
β-strand	147-149	3	25
β-strand	154-156	3	25
α-helix	157-159	3
β-strand	161-164	4	24

Chain F: 5 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	7-12	6	26
β-strand	17-23	7	26
β-strand	33-39	7	27
β-strand	46-48	3	27
β-strand	51-52	2	26
β-strand	57-63	7	26
β-strand	78-86	9	27
β-strand	89-98	10	27
α-helix	100-102	3
β-strand	104	1	26
α-helix	106-109	4
β-strand	110-117	8	28
β-strand	121-127	7	28
α-helix	133-135	3
β-strand	139-146	8	29
β-strand	158-160	3	29
β-strand	166-170	5	28
β-strand	177-186	10	29
α-helix	194-200	7
β-strand	201-204	4	29
α-helix	205-207	3

Chain G: 4 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	39-43	5	30
β-strand	47-51	5	30
β-strand	64-69	6	31
β-strand	78-79	2	31
β-strand	83-86	4	30
β-strand	89-96	8	30
α-helix	97-99	3
β-strand	106-111	6	31
β-strand	119-124	6	31
α-helix	126-128	3
β-strand	130-131	2	30
α-helix	132-135	4
β-strand	136-142	7	32
β-strand	148-153	6	32
β-strand	161-168	8	33
β-strand	176-180	5	33
β-strand	185-188	4	32
β-strand	197-205	9	33
α-helix	214-221	8
β-strand	222-224	3	33

Chain H: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	4-28	25
α-helix	36-39	4
β-strand	44	1	34
β-strand	47	1	35
α-helix	53-56	4
α-helix	57-60	4
α-helix	63-73	11
α-helix	82-97	16
β-strand	107	1	35
β-strand	112	1	34
α-helix	114-132	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-2 receptor alpha chain	A, E	protein	225	Homo sapiens	P01589 (AlphaFold model)
Interleukin-2 receptor beta chain	B, F	protein	219	Homo sapiens	P14784 (AlphaFold model)
Cytokine receptor common gamma chain	C, G	protein	247	Homo sapiens	P31785 (AlphaFold model)
Interleukin-2	D, H	protein	133	Homo sapiens	P60568 (AlphaFold model)

Sequence of entity 1 (A, E), FASTA

>2ERJ_1 Interleukin-2 receptor alpha chain (chains A, E)
GMLSLELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGSSSHSSW
DNQCQCTSSATRSTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEAT
ERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGE
EKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSTGHHHHHH

Sequence of entity 2 (B, F), FASTA

>2ERJ_2 Interleukin-2 receptor beta chain (chains B, F)
GMLSLAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQ
ASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVV
HVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPD
TQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKTGHHHHHH

Sequence of entity 3 (C, G), FASTA

>2ERJ_3 Cytokine receptor common gamma chain (chains C, G)
GMLSLLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWQSS
SEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPRE
PRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSW
TEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPRT
GHHHHHH

Sequence of entity 4 (D, H), FASTA

>2ERJ_4 Interleukin-2 (chains D, H)
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLE
EELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNR
WITFAQSIISTLT

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	4

Primary citation

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor. Stauber, D.J., Debler, E.W., Horton, P.A. et al. Proc Natl Acad Sci U S A (2006) 103:2793. DOI 10.1073/pnas.0511161103 · PubMed

Other PDB entries of the same protein (UniProt P01589 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6YIO 1.83 Å, Crystal structure of FAB RG6292 in complex with CD25 ecd
2B5I 2.3 Å, cytokine receptor complex
1Z92 2.8 Å, structure of interleukin-2 with its alpha receptor
3NFP 2.86 Å, Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with…
3IU3 2.9 Å, Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex…
9KMC 2.97 Å, Cryo-EM structure of the heterotrimeric interleukin-2 receptor in complex with…
7F9W 3.2 Å, CD25 in complex with Fab
7ZMZ 3.2 Å, Engineered Interleukin 2 bound to CD25 receptor
6VWU 3.4 Å, X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and…

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