Laminin subunit gamma-1 (Lamc1) is a 1607-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02468.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 58% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway (PubMed:9454835)
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) (PubMed:9454835). Gamma-1 is also a subunit of laminin-2 (laminin-211 or merosin),…
Secreted, extracellular space, extracellular matrix, basement membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1KLO | X-ray | 2.1 Å | A=771-932 |
| 5MC9 | X-ray | 2.13 Å | C=1548-1607 |
| 1NPE | X-ray | 2.3 Å | B=769-932 |
| 4AQT | X-ray | 3.2 Å | A=33-395 |
| 1TLE | NMR | A=824-881 |
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