Tubulin alpha-1A chain (TUBA1A) is a 451-residue protein from Sus scrofa. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02550.
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The mean pLDDT of this model is 90.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365)
Heterodimer of alpha- and beta-tubulin (PubMed:7225365). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM (By similarity). Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural…
Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, flagellum axoneme
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7X4N | X-ray | 2.88 Å | A=1-451 |
| 9T1D | EM | 2.9 Å | A=1-439 |
| 6MZG | X-ray | 3.21 Å | A/C/G/I=1-451 |
| 7U0F | EM | 3.53 Å | A/C=1-451 |
| 8QAU | EM | 3.54 Å | C=1-451 |
| 8X9P | EM | 3.54 Å | A=1-439 |
| 6MZE | X-ray | 3.6 Å | A/C/H/J/O/Q/V/X=1-451 |
| 6KIQ | EM | 3.62 Å | a=2-439 |
| 1TUB | X-ray | 3.7 Å | A=1-440 |
| 9EDT | EM | 3.7 Å | A=1-451 |
| 9EEB | EM | 3.7 Å | A=1-451 |
| 9EDR | EM | 3.8 Å | A=1-451 |
| 9EDS | EM | 3.8 Å | A=1-451 |
| 7RX0 | EM | 3.89 Å | A=1-451 |
| 7RS5 | EM | 3.9 Å | A/C/E/G/I/L/N/P/R=1-451 |
| 6KIO | EM | 3.94 Å | a=2-439 |
| 1FFX | X-ray | 3.95 Å | A/C=1-451 |
| 6MLQ | EM | 4.2 Å | A=1-451 |
| 6MLR | EM | 4.2 Å | A=1-451 |
| 6MZF | X-ray | 4.4 Å | A/C/H/J/O/Q/V/X=1-451 |
Showing 20 of 41 experimental structures (best resolution first).
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