Acetylcholine receptor subunit alpha (CHRNA1) is a 457-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02708.
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The mean pLDDT of this model is 84.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane
One of the alpha chains that assemble within the acetylcholine receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996)
Postsynaptic cell membrane, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9DMS | EM | 1.92 Å | A/C=1-457 |
| 9DMG | EM | 2.05 Å | A/C=1-457 |
| 9DMH | EM | 2.06 Å | A/C=1-457 |
| 9DMQ | EM | 2.06 Å | A/C=1-457 |
| 9DMV | EM | 2.13 Å | A/C=1-457 |
| 9DMT | EM | 2.18 Å | A/C=1-457 |
| 9DMJ | EM | 2.19 Å | A/C=1-457 |
| 4ZJS | X-ray | 2.23 Å | A/B/C/D/E=21-52, A/B/C/D/E=81-101 |
| 9DML | EM | 2.24 Å | E/F=1-457 |
| 9DMK | EM | 2.46 Å | A/C=1-457 |
| 9GU1 | EM | 2.48 Å | A/L=21-457 |
| 5HBT | X-ray | 2.61 Å | B=21-231 |
| 9GU3 | EM | 2.64 Å | A/L=21-457 |
| 9GU2 | EM | 2.73 Å | A/L=21-457 |
| 9GU0 | EM | 2.96 Å | A/L=21-457 |
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