Nucleoprotein (NP) is a 498-residue protein from Influenza A virus. This is its AlphaFold structure prediction, created 3 Sept 2026. UniProt accession: P03466.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 77.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host…
Homomultimerizes to form the nucleocapsid. May bind host exportin-1/XPO1. Binds to viral genomic RNA. Protein-RNA contacts are mediated by a combination of electrostatic interactions between positively charged residues and the phosphate backbone and planar interactions between aromatic side chains and bases
Virion, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NPZ | X-ray | 1.43 Å | C=252-260 |
| 5NQ3 | X-ray | 1.57 Å | C/F=252-260 |
| 2BST | X-ray | 2.1 Å | C=383-391 |
| 5V5O | X-ray | 2.24 Å | A/B=198-216 |
| 4ZDU | X-ray | 2.3 Å | B=2-15 |
| 4NQV | X-ray | 2.39 Å | M/N/O/P/Q/R=44-52 |
| 9OUC | X-ray | 2.73 Å | A/B=8-498 |
| 2WFS | EM | 12.0 Å | A/B/C/D/E/F/G/H/I=8-498 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.