Non-structural protein 1 (NS) is a 281-residue protein from Influenza B virus. This is its AlphaFold structure prediction, created 1 Jan 2024. UniProt accession: P03502.
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The mean pLDDT of this model is 78.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins. Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA
Homodimer. Interacts with and inhibits human G1P2 conjugation by UBE1L
Host cytoplasm, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3RT3 | X-ray | 2.01 Å | C=1-103 |
| 1XEQ | X-ray | 2.1 Å | A/B=1-103 |
| 3SDL | X-ray | 2.29 Å | A/B=1-103 |
| 3R66 | X-ray | 2.3 Å | A/B=1-103 |
| 6JH0 | X-ray | 2.4 Å | A/C=1-103 |
| 6J62 | X-ray | 2.49 Å | C=1-103 |
| 6JH1 | X-ray | 3.0 Å | A/B=1-103 |
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