Fructose-bisphosphate aldolase A (ALDOA) is a 364-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04075.
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The mean pLDDT of this model is 96.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 93% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, also functions as a scaffolding protein (By similarity). In response to glucose deprivation, FBP dissociates from aldolase and acts as an adapter that promotes AMP-activated protein kinase (AMPK) activity: mechanistically, associates with transient receptor potential channels TrpV (TRPV1-TRPV4), promoting inhibition of the V-ATPase complex on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis (By similarity)
Homotetramer (By similarity). Interacts with SNX9 and WAS (By similarity). Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+) (PubMed:18214967)
Cytoplasm, myofibril, sarcomere, I band, Cytoplasm, myofibril, sarcomere, M line
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6XML | X-ray | 1.88 Å | A/B=1-364 |
| 5KY6 | X-ray | 1.94 Å | A/B/C/D=2-364 |
| 6XMH | X-ray | 1.95 Å | A/B=1-364 |
| 1ALD | X-ray | 2.0 Å | A=2-364 |
| 2ALD | X-ray | 2.1 Å | A=2-364 |
| 6XMM | X-ray | 2.11 Å | A/B=1-364 |
| 6XMO | X-ray | 2.6 Å | A/B=1-364 |
| 4ALD | X-ray | 2.8 Å | A=2-364 |
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