Guanine nucleotide-binding protein G(t) subunit alpha-1 (GNAT1) is a 350-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04695.
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The mean pLDDT of this model is 94.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that transduces signals from the G protein-coupled photoreceptor rhodopsin (RHO) (PubMed:6586721, PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:8259210, PubMed:31300275). Essential for normal RHO-mediated light perception in retinal rod photoreceptors (By similarity). Functions as a GTPase, cycling between an active GTP-bound state and an inactive GDP-bound state (PubMed:21285355, PubMed:28655769, PubMed:7969474, PubMed:8208289, PubMed:8259210, PubMed:16469737). Under dim light conditions, photoactivated RHO promotes GDP release and GTP binding (PubMed:21285355, PubMed:28655769). In its active…
Heterotrimeric G proteins are composed of alpha, beta and gamma subunits (PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:31300275). The alpha chain contains the guanine nucleotide-binding site (PubMed:21285355, PubMed:7969474, PubMed:8208289, PubMed:8259210). Interacts with RHO; interaction promotes GDP release and GTP binding (PubMed:18818650, PubMed:21285355, PubMed:21389983,…
Photoreceptor outer segment membrane, Membrane, Photoreceptor inner segment
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1TAD | X-ray | 1.7 Å | A/B/C=27-350 |
| 1TAG | X-ray | 1.8 Å | A=27-350 |
| 1GOT | X-ray | 2.0 Å | A=1-350 |
| 1FQJ | X-ray | 2.02 Å | A/D=26-215, A/D=296-350 |
| 1TND | X-ray | 2.2 Å | A/B/C=27-350 |
| 1FQK | X-ray | 2.3 Å | A/C=26-215, A/C=296-350 |
| 4J4Q | X-ray | 2.65 Å | B=340-350 |
| 3PQR | X-ray | 2.85 Å | B=340-350 |
| 3V00 | X-ray | 2.9 Å | A/B/C=1-215, A/B/C=244-251, A/B/C=296-350 |
| 4BEY | X-ray | 2.9 Å | B=340-350 |
| 2X72 | X-ray | 3.0 Å | B=340-350 |
| 3DQB | X-ray | 3.2 Å | B=340-350 |
| 7JSN | EM | 3.2 Å | E/F=1-350 |
| 8XGR | EM | 3.2 Å | G=1-350 |
| 6OYA | EM | 3.3 Å | A=1-350 |
| 6OY9 | EM | 3.9 Å | A=1-350 |
| 1AQG | NMR | A=340-350 | |
| 1LVZ | NMR | A=340-350 |
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