Alpha-actinin A (abpA) is a 861-residue protein from Dictyostelium discoideum. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05095.
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The mean pLDDT of this model is 83.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 55% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton
Homodimer; antiparallel
Cytoplasm, Cytoplasm, cell cortex, Contractile vacuole, Cytoplasmic vesicle, phagosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9IHL | X-ray | 2.02 Å | A=265-502 |
| 5I4E | X-ray | 2.25 Å | A=265-489 |
| 1G8X | X-ray | 2.8 Å | A/B=266-502 |
| 4PD3 | X-ray | 2.84 Å | A/B=265-502 |
| 5JLH | EM | 3.9 Å | F/G=265-502 |
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