Transcription factor Jun (JUN) is a 331-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05412.
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The mean pLDDT of this model is 61.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 33% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic…
Heterodimer with either BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). Heterodimer with FOS (By similarity). Heterodimer with FOSB isoform 1 and 2 (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y3V | X-ray | 1.5 Å | P=262-273 |
| 5T01 | X-ray | 1.89 Å | A/B=254-315 |
| 5FV8 | X-ray | 1.99 Å | D/E=277-308 |
| 1JNM | X-ray | 2.2 Å | A/B=254-315 |
| 8SOS | X-ray | 2.33 Å | A/E=276-327 |
| 1A02 | X-ray | 2.7 Å | J=253-308 |
| 1T2K | X-ray | 3.0 Å | C=254-314 |
| 1FOS | X-ray | 3.05 Å | F/H=254-315 |
| 1S9K | X-ray | 3.1 Å | E=257-308 |
| 1JUN | NMR | A/B=276-315 |
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