Prostaglandin G/H synthase 1 (PTGS1) is a 600-residue protein from Ovis aries. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05979.
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The mean pLDDT of this model is 93.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 92% |
| 70 to 90 | Confident: backbone generally right | 0% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response (PubMed:9448728). The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form…
Homodimer
Endoplasmic reticulum membrane, Microsome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1Q4G | X-ray | 2.0 Å | A/B=32-584 |
| 2AYL | X-ray | 2.0 Å | A/B=32-584 |
| 4O1Z | X-ray | 2.4 Å | A/B=32-600 |
| 3N8Y | X-ray | 2.6 Å | A/B=32-584 |
| 1EQG | X-ray | 2.61 Å | A/B=21-600 |
| 1HT8 | X-ray | 2.69 Å | A/B=33-583 |
| 1EQH | X-ray | 2.7 Å | A/B=21-600 |
| 2OYU | X-ray | 2.7 Å | P=1-600 |
| 1HT5 | X-ray | 2.75 Å | A/B=33-583 |
| 3KK6 | X-ray | 2.75 Å | A/B=32-584 |
| 3N8W | X-ray | 2.75 Å | A/B=32-584 |
| 3N8X | X-ray | 2.75 Å | A/B=32-584 |
| 5WBE | X-ray | 2.75 Å | A/B=1-600 |
| 2OYE | X-ray | 2.85 Å | P=1-600 |
| 1IGZ | X-ray | 2.9 Å | A=25-600 |
| 3N8Z | X-ray | 2.9 Å | A/B=32-584 |
| 5U6X | X-ray | 2.93 Å | A/B=1-600 |
| 1DIY | X-ray | 3.0 Å | A=32-584 |
| 1FE2 | X-ray | 3.0 Å | A=25-600 |
| 3N8V | X-ray | 3.05 Å | A/B=32-584 |
Showing 20 of 30 experimental structures (best resolution first).
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