Progesterone receptor (PGR) is a 933-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06401.
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The mean pLDDT of this model is 56.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor
Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by…
Nucleus, Cytoplasm, Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1SQN | X-ray | 1.45 Å | A/B=673-933 |
| 1SR7 | X-ray | 1.46 Å | A/B=676-933 |
| 3ZR7 | X-ray | 1.65 Å | A/B=678-933 |
| 1A28 | X-ray | 1.8 Å | A/B=678-933 |
| 2W8Y | X-ray | 1.8 Å | A/B=678-933 |
| 3ZRB | X-ray | 1.8 Å | A/B=678-933 |
| 3G8O | X-ray | 1.9 Å | A/B=673-933 |
| 3ZRA | X-ray | 1.9 Å | A/B=678-933 |
| 4APU | X-ray | 1.9 Å | A/B=678-933 |
| 1ZUC | X-ray | 2.0 Å | A/B=676-933 |
| 2OVH | X-ray | 2.0 Å | A=678-933 |
| 3KBA | X-ray | 2.0 Å | A/B=681-933 |
| 4A2J | X-ray | 2.0 Å | A/B=678-933 |
| 3HQ5 | X-ray | 2.1 Å | A/B=678-933 |
| 3D90 | X-ray | 2.26 Å | A/B=676-933 |
| 5CC0 | X-ray | 2.4 Å | A/B=558-642 |
| 4OAR | X-ray | 2.41 Å | A=678-933 |
| 2C7A | X-ray | 2.5 Å | A/B=563-640 |
| 2OVM | X-ray | 2.6 Å | A=678-933 |
| 1E3K | X-ray | 2.8 Å | A/B=676-933 |
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