Early growth response protein 1 (Egr1) is a 533-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08046.
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The mean pLDDT of this model is 49.4 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 2% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 73% |
What pLDDT means and how to read it
Transcriptional regulator (PubMed:15958557, PubMed:8336701, PubMed:8703054). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15958557, PubMed:2028256, PubMed:8703054, PubMed:8939742). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557). Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557). Activates expression of p53/TP53…
Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1LLM | X-ray | 1.5 Å | C/D=363-412 |
| 1A1H | X-ray | 1.6 Å | A=333-421 |
| 1A1I | X-ray | 1.6 Å | A=333-421 |
| 1AAY | X-ray | 1.6 Å | A=333-421 |
| 1JK2 | X-ray | 1.65 Å | A=333-421 |
| 1A1G | X-ray | 1.9 Å | A=333-421 |
| 1A1K | X-ray | 1.9 Å | A=333-421 |
| 1JK1 | X-ray | 1.9 Å | A=333-421 |
| 1A1J | X-ray | 2.0 Å | A=333-421 |
| 1G2F | X-ray | 2.0 Å | C/F=333-421 |
| 1A1F | X-ray | 2.1 Å | A=333-421 |
| 1ZAA | X-ray | 2.1 Å | C=332-418 |
| 1G2D | X-ray | 2.2 Å | C/F=333-421 |
| 1P47 | X-ray | 2.2 Å | A/B=333-419 |
| 1A1L | X-ray | 2.3 Å | A=333-421 |
| 1F2I | X-ray | 2.35 Å | G/H/I/J/K/L=319-389 |
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