Signal recognition particle receptor subunit alpha (SRPRA) is a 638-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08240.
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The mean pLDDT of this model is 73.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957)
Heterodimer with SRPRB (PubMed:16439358). Interacts with the signal recognition particle (SRP) complex subunit SRP54 (PubMed:34020957)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2FH5 | X-ray | 2.45 Å | A=3-176 |
| 6Y32 | X-ray | 2.6 Å | B/D/F/H=332-638 |
| 5L3Q | X-ray | 3.2 Å | B/D=1-638 |
| 7NFX | EM | 3.2 Å | y=1-638 |
| 2GO5 | EM | 7.4 Å | 1=3-176 |
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