Cathepsin G (CTSG) is a 255-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08311.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Serine protease with trypsin- and chymotrypsin-like specificity (PubMed:29652924, PubMed:8194606). Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity (PubMed:2116408, PubMed:2117044). Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu (PubMed:29652924). Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site (PubMed:29652924). Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor (PubMed:10702240, PubMed:3390156).…
(Microbial infection) Interacts with CASP4; the interaction is promoted by the Td92 surface protein of the periodontal pathogen T.denticola and leads to CASP4 activation
Cell membrane, Cytoplasmic granule, Secreted, Cytoplasm, cytosol, Lysosome, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7H6G | X-ray | 1.21 Å | A/B=21-255 |
| 6VTM | X-ray | 1.6 Å | A/C/D/G=21-244 |
| 1CGH | X-ray | 1.8 Å | A=21-244 |
| 8G25 | X-ray | 1.8 Å | A/F/I=21-243 |
| 8G24 | X-ray | 1.82 Å | A=21-243 |
| 1T32 | X-ray | 1.85 Å | A=21-244 |
| 8D4V | X-ray | 1.85 Å | A/C=21-243 |
| 8G26 | X-ray | 1.85 Å | A=21-243 |
| 1AU8 | X-ray | 1.9 Å | A=21-244 |
| 7H6H | X-ray | 1.94 Å | A=21-255 |
| 8D4S | X-ray | 1.95 Å | A/C/E/G=21-243 |
| 9ASX | X-ray | 1.96 Å | A=21-243 |
| 9ATK | X-ray | 2.11 Å | B/E/H/K=21-243 |
| 8D7K | X-ray | 3.1 Å | C/F/I/L=21-243 |
| 1KYN | X-ray | 3.5 Å | A/B=21-255 |
| 8D7I | X-ray | 3.63 Å | C/F/I/L/O/R=21-243 |
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