Coagulation factor VII (F7) is a 466-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08709.
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The mean pLDDT of this model is 82.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951)
Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6R2W | X-ray | 1.25 Å | H=213-466, L=61-203 |
| 5PAG | X-ray | 1.36 Å | A=149-212, B=213-466 |
| 5PAX | X-ray | 1.36 Å | A=149-212, C=213-466 |
| 4YLQ | X-ray | 1.4 Å | H=213-466, L=61-212 |
| 5PAO | X-ray | 1.4 Å | A=149-212, C=213-466 |
| 5PAV | X-ray | 1.4 Å | A=149-212, C=213-466 |
| 5L0S | X-ray | 1.45 Å | B=105-145 |
| 5PAE | X-ray | 1.45 Å | A=149-212, B=213-466 |
| 5PB2 | X-ray | 1.45 Å | A=149-212, C=213-466 |
| 5PAS | X-ray | 1.48 Å | A=149-212, C=213-466 |
| 5PAC | X-ray | 1.5 Å | A=149-212, B=213-466 |
| 5PAF | X-ray | 1.5 Å | A=149-212, B=213-466 |
| 4JZE | X-ray | 1.52 Å | H=213-466, L=150-204 |
| 5PA9 | X-ray | 1.55 Å | A=149-212, C=213-466 |
| 5PAU | X-ray | 1.55 Å | A=149-212, C=213-466 |
| 5PAK | X-ray | 1.56 Å | A=149-212, C=213-466 |
| 8QOD | X-ray | 1.57 Å | A=63-203, B=213-466 |
| 5PAQ | X-ray | 1.59 Å | A=149-212, B=213-466 |
| 2BZ6 | X-ray | 1.6 Å | H=213-466, L=150-202 |
| 5PAM | X-ray | 1.6 Å | A=149-212, B=213-466 |
Showing 20 of 114 experimental structures (best resolution first).
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