P0ADV7: Intermembrane phospholipid transport system binding protein MlaC (mlaC)

Intermembrane phospholipid transport system binding protein MlaC (mlaC) is a 211-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0ADV7.

Gene
mlaC
Organism
Escherichia coli (strain K12)
Length
211 residues
Mean pLDDT
91.9
Model
AF-P0ADV7-F1 v6
Model created
1 Aug 2025
PDB structures
6

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Model confidence (pLDDT)

The mean pLDDT of this model is 91.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate86%
70 to 90Confident: backbone generally right2%
50 to 70Low: treat with caution10%
Below 50Very low: often disordered regions2%

What pLDDT means and how to read it

Function

Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane

Subunit structure

Interacts with the MlaA-OmpF outer membrane complex and with the inner membrane ABC transporter complex MlaFEDB, via direct interaction with MlaD

Subcellular location

Periplasm

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
5UWAX-ray1.5 ÅA/B=22-211
6GKIX-ray2.23 ÅA/B=22-211
7VR6X-ray2.5 ÅA=14-211
8I8XEM3.25 ÅF=21-211
8OJ4EM4.35 ÅH=1-211
8OJGEM4.38 ÅG/H=1-211

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