Tau-theraphotoxin-Hs1a is a 79-residue protein from Cyriopagopus schmidti. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0CH43.
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The mean pLDDT of this model is 84.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Selectively activates the heat-activated TRPV1 channel. It binds to TRPV1 in an open state-dependent manner, trapping it there to produce irreversible currents (PubMed:20510930, PubMed:26880553, PubMed:27281200). It binds to the outer edge of the external pore of TRPV1 in a counterclockwise configuration, using a limited protein-protein interface and inserting hydrophobic residues into the bilayer (PubMed:26880553, PubMed:27281200). It also partitions naturally into membranes, with the two lobes exhibiting opposing energetics for membrane partitioning (K1) and channel activation (K2) (PubMed:26880553). In addition, the toxin disrupts a cluster of hydrophobic residues behind the selectivity…
Interacts with TRPV1 (2 toxins (4 moieties) bind 1 channel (homotetramer))
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5IRX | EM | 2.95 Å | E/F=1-75 |
| 7L2T | EM | 3.08 Å | E/F=1-75 |
| 7L2R | EM | 3.3 Å | E/F=1-75 |
| 7L2U | EM | 3.47 Å | E/F=1-75 |
| 7L2M | EM | 3.84 Å | E/F=1-75 |
| 2N9Z | NMR | A=1-42 | |
| 2NAJ | NMR | A=43-75 | |
| 6CUC | NMR | A=1-79 |
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