ORF8 protein (8) is a 121-residue protein from Severe acute respiratory syndrome coronavirus 2. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P0DTC8.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 52.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 0% |
| 50 to 70 | Low: treat with caution | 62% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Plays a role in modulating the host immune response (PubMed:31986261, PubMed:35343786, PubMed:36689483). May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increased secretion of pro-inflammatory factors (PubMed:35343786, PubMed:36689483). Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway (PubMed:33723527, PubMed:36689483). May act by down-regulating major histocompability complex class I (MHC-I) at cell surface (PubMed:34021074, PubMed:35157849). May inhibit expression of some members of the IFN-stimulated gene (ISG) family…
Homodimer (PubMed:33361333, PubMed:35157849). Interacts with host IL17RA (PubMed:33060197, PubMed:35343786). Interacts with host IL17RC (PubMed:35343786). Interacts with host MHC-I (PubMed:34021074)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7JX6 | X-ray | 1.61 Å | A/B=18-121 |
| 7F5F | X-ray | 1.62 Å | A=18-121 |
| 7JTL | X-ray | 2.04 Å | A/B=18-121 |
| 7XMN | X-ray | 2.3 Å | B=16-121 |
| 7MX9 | X-ray | 2.6 Å | A=15-121 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.