Protein crumbs (crb) is a 2146-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10040.
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The mean pLDDT of this model is 66.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 40% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Plays a central role in cell polarity establishment, and contributes to the organization of zonula adherens, epithelial morphogenesis, and tissue growth (PubMed:10102271, PubMed:11740560, PubMed:12900452, PubMed:2344615). Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex (PubMed:10102271, PubMed:11076972, PubMed:11740560, PubMed:12900452). Controls the coalescence of the spots of zonula adherens (ZA) into an adhesive ring around the cells (PubMed:11740560). It may act as a signal (PubMed:2344615). Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the…
Component of the SAC complex, a complex composed of crb, Patj and sdt (PubMed:10102271, PubMed:11076972, PubMed:11740560). May interact with the par-6 complex, which is composed of par-6, baz and aPKC, via its interaction with Patj (PubMed:10102271, PubMed:11076972, PubMed:12900452). Interacts with other proteins with Patj and sdt via its short cytoplasmic tail (PubMed:11740560). Component of…
Apical cell membrane, Cytoplasm, cytoskeleton, spindle, Cell projection, rhabdomere membrane
Compare the prediction with experimentally determined structures of the same protein:
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