Transforming growth factor beta-3 proprotein (TGFB3) is a 412-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10600.
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The mean pLDDT of this model is 76.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively
Interacts with ASPN (PubMed:8819159). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote…
Secreted, extracellular space, extracellular matrix, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1TGJ | X-ray | 2.0 Å | A=301-412 |
| 1KTZ | X-ray | 2.15 Å | A=301-412 |
| 4UM9 | X-ray | 2.5 Å | E/F=259-269 |
| 8V52 | X-ray | 2.5 Å | A/B=301-412 |
| 8VS6 | EM | 2.73 Å | E=24-412 |
| 8VSB | EM | 2.93 Å | A/B=24-412 |
| 2PJY | X-ray | 3.0 Å | A=301-412 |
| 9B9F | X-ray | 3.0 Å | A/B/F/G=301-412 |
| 3EO1 | X-ray | 3.1 Å | C/F/I/L=301-412 |
| 1TGK | X-ray | 3.3 Å | A=301-412 |
| 9FK5 | EM | 4.1 Å | A/B=301-412 |
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