Muscarinic acetylcholine receptor M1 (CHRM1) is a 460-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11229.
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The mean pLDDT of this model is 74.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Interacts with GPRASP2 (PubMed:15086532). Interacts with TMEM147 (PubMed:21056967)
Cell membrane, Postsynaptic cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6ZFZ | X-ray | 2.17 Å | A=27-219, A=355-438 |
| 6ZG4 | X-ray | 2.33 Å | A=27-219, A=355-438 |
| 6ZG9 | X-ray | 2.5 Å | A=27-219, A=355-438 |
| 6WJC | X-ray | 2.55 Å | A=2-218, A=355-460 |
| 5CXV | X-ray | 2.7 Å | A=2-218, A=355-460 |
| 6OIJ | EM | 3.3 Å | R=2-460 |
| 9JEA | EM | 3.4 Å | A=25-412, A=414-417 |
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