P11230: Acetylcholine receptor subunit beta (CHRNB1)

Acetylcholine receptor subunit beta (CHRNB1) is a 501-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11230.

Gene: CHRNB1
Organism: Homo sapiens
Length: 501 residues
Mean pLDDT: 79.4
Model: AF-P11230-F1 v6
Model created: 1 Aug 2025
PDB structures: 13

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Model confidence (pLDDT)

The mean pLDDT of this model is 79.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	45%
70 to 90	Confident: backbone generally right	32%
50 to 70	Low: treat with caution	7%
Below 50	Very low: often disordered regions	16%

What pLDDT means and how to read it

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Subunit structure

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996)

Subcellular location

Postsynaptic cell membrane, Cell membrane

Disease associations

Myasthenic syndrome, congenital, 2A, slow-channel (CMS2A)
Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency (CMS2C)

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
9DMS	EM	1.92 Å	E=1-501
9DMG	EM	2.05 Å	E=1-501
9DMH	EM	2.06 Å	E=1-501
9DMQ	EM	2.06 Å	E=1-501
9DMV	EM	2.13 Å	E=1-501
9DMT	EM	2.18 Å	E=1-501
9DMJ	EM	2.19 Å	E=1-501
9DML	EM	2.24 Å	G=1-501
9DMK	EM	2.46 Å	E=1-501
9GU1	EM	2.48 Å	B=24-501
9GU3	EM	2.64 Å	B=24-501
9GU2	EM	2.73 Å	B=24-501
9GU0	EM	2.96 Å	B=24-501

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