DNA-directed RNA polymerase II subunit RPB1 (POLR2A) is a 1970-residue protein from Cricetulus griseus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11414.
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The mean pLDDT of this model is 74.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in…
Component of the RNA polymerase II (Pol II) core complex consisting of 12 subunits: a ten-subunit catalytic core composed of POLR2A/RPB1, POLR2B/RPB2, POLR2C/RPB3, POLR2I/RPB9, POLR2J/RPB11, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5 and a mobile stalk composed of two subunits POLR2D/RPB4 and POLR2G/RPB7, protruding from the core and functioning primarily in…
Nucleus, Cytoplasm, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OOB | EM | 2.7 Å | A=1-1970 |
| 7OO3 | EM | 2.8 Å | A=1-1970 |
| 8OEW | EM | 2.8 Å | A=1-1970 |
| 8OEV | EM | 2.86 Å | A=1-1970 |
| 7OOP | EM | 2.9 Å | A=1-1970 |
| 7OPC | EM | 3.0 Å | A=1-1970 |
| 7OPD | EM | 3.0 Å | A=1-1970 |
| 8OEU | EM | 3.04 Å | A=1-1970 |
| 8OF0 | EM | 3.05 Å | A=1-1970 |
| 8P4B | EM | 3.2 Å | A=1-1970 |
| 7OKX | EM | 3.3 Å | A=1-1970 |
| 7B0Y | EM | 3.6 Å | A=1-1970 |
| 8P4D | EM | 3.6 Å | A=1-1970 |
| 8P4C | EM | 3.8 Å | A=1-1970 |
| 8P4E | EM | 3.9 Å | A=1-1970 |
| 8P4F | EM | 4.0 Å | A=1-1970 |
| 7OKY | EM | 4.14 Å | A=1-1970 |
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