Aromatase (CYP19A1) is a 503-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11511.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561). Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to…
Endoplasmic reticulum membrane, Microsome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3S79 | X-ray | 2.75 Å | A=1-503 |
| 5JKV | X-ray | 2.75 Å | A=1-503 |
| 3EQM | X-ray | 2.9 Å | A=1-503 |
| 5JKW | X-ray | 3.0 Å | A=1-503 |
| 5JL6 | X-ray | 3.0 Å | A=1-503 |
| 5JL7 | X-ray | 3.1 Å | A=1-503 |
| 5JL9 | X-ray | 3.1 Å | A=1-503 |
| 3S7S | X-ray | 3.21 Å | A=1-503 |
| 4KQ8 | X-ray | 3.29 Å | A=45-503 |
| 4GL5 | X-ray | 3.48 Å | A=1-503 |
| 4GL7 | X-ray | 3.9 Å | A=1-503 |
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