High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is a 257-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P12319.
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The mean pLDDT of this model is 84.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic…
Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Interacts with IGHE (via CH3 region)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1F2Q | X-ray | 2.4 Å | A=26-201 |
| 1RPQ | X-ray | 3.0 Å | A/B/C/D=26-201 |
| 8YWA | EM | 3.14 Å | A=26-257 |
| 1J86 | X-ray | 3.2 Å | A/B=26-201 |
| 1J87 | X-ray | 3.2 Å | A=26-197 |
| 1J88 | X-ray | 3.2 Å | A/B/C/D/E=26-197 |
| 2Y7Q | X-ray | 3.4 Å | A=26-209 |
| 1F6A | X-ray | 3.5 Å | A=26-201 |
| 8K7R | EM | 3.56 Å | A=1-257 |
| 8Z0T | EM | 3.58 Å | A=1-257 |
| 8C1B | EM | 3.8 Å | R=29-197 |
| 8YVU | EM | 3.9 Å | A/E=201-237 |
| 1J89 | X-ray | 4.1 Å | A/B/C/D/E=26-197 |
| 8C1C | EM | 4.1 Å | R=29-199 |
| 9EQ3 | EM | 6.9 Å | R=29-199 |
| 7SHT | EM | 7.29 Å | A=30-197 |
| 9EQ4 | EM | 8.4 Å | R=29-199 |
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