1J89: PDB entry 1J89

Human high affinity fc receptor fc(epsilon)ri(alpha), tetragonal crystal form 2. Determined by X-ray diffraction at 4.1 Å resolution. Released 29 Aug 2001.

Method: X-ray diffraction
Resolution: 4.1 Å
Organism: Homo sapiens
Chains: 5
Atoms: 7,660
Mol. weight: 111.35 kDa
Ligands: NAG
Released: 29 Aug 2001

Explore 1J89 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1J89 contains 25 α-helices and 100 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C, D and E: 5 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	1
β-strand	15-17	3	2
β-strand	22-25	4	1
β-strand	40-41	2	3
β-strand	44-45	2	3
β-strand	52-55	4	1
α-helix	60-62	3
β-strand	64-66	3	4
β-strand	79-81	3	4
β-strand	82-84	3	2
β-strand	88-92	5	5
β-strand	96-98	3	6
β-strand	103-104	2	7
β-strand	105-109	5	5
α-helix	110-112	3
β-strand	115-122	8	8
β-strand	125-130	6	8
β-strand	137-138	2	7
α-helix	141-142	2
α-helix	143-145	3
β-strand	147-155	9	8
β-strand	158-161	4	8
α-helix	162-164	3
β-strand	165-167	3	8
β-strand	168-170	3	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
High affinity immunoglobulin epsilon receptor alpha-subunit	A, B, C, D, E	protein	172	Homo sapiens	P12319 (AlphaFold model)

Sequence of entity 1 (A, B, C, D, E), FASTA

>1J89_1 HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR ALPHA-SUBUNIT (chains A, B, C, D, E)
VPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKF
EDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIY
YKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKA

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	20

Primary citation

The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. Garman, S.C., Sechi, S., Kinet, J.P. et al. J Mol Biol (2001) 311:1049-1062. DOI 10.1006/jmbi.2001.4929 · PubMed

Other PDB entries of the same protein (UniProt P12319 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1F2Q 2.4 Å, Crystal structure of the human high-affinity IgE receptor
1RPQ 3.0 Å, High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta'…
8YWA 3.14 Å, The structure of IgE receptor binding to IgE
1J86 3.2 Å, Human high affinity fc receptor fc(epsilon)ri(alpha), monoclinic crystal form 2
1J87 3.2 Å, Human high affinity fc receptor fc(epsilon)ri(alpha), hexagonal crystal form 1
1J88 3.2 Å, Human high affinity fc receptor fc(epsilon)ri(alpha), tetragonal crystal form 1
2Y7Q 3.4 Å, The high-affinity complex between IgE and its receptor fc epsilon ri
1F6A 3.5 Å, Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)
8K7R 3.56 Å, Human Fc epsilon RI in complex with hIgE Fc (TMD disordered)
8Z0T 3.58 Å, Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)
8C1B 3.8 Å, Focused map for structure of IgE bound to the ectodomain of FceRIa
8YVU 3.9 Å, structure of Ige receptor

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