Fibronectin-binding protein A (fnbA) is a 1018-residue protein from Staphylococcus aureus (strain NCTC 8325 / PS 47). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P14738.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 53.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
Possesses multiple, substituting fibronectin (Fn) binding regions, each capable of conferring adherence to both soluble and immobilized forms of Fn. This confers to S.aureus the ability to invade endothelial cells both in vivo and in vitro, without requiring additional factors, although in a slow and inefficient way through actin rearrangements in host cells. This invasion process is mediated by integrin alpha-5/beta-1. Promotes bacterial attachment to both soluble and immobilized forms of fibrinogen (Fg) by means of a unique binding site localized within the 17 C-terminal residues of the gamma-chain of human Fg. Both plasma proteins (Fn and Fg) function as a bridge between bacterium and…
Secreted, cell wall
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3CAL | X-ray | 1.7 Å | B/D=654-672 |
| 2RKY | X-ray | 1.8 Å | B/D=508-530 |
| 4B60 | X-ray | 1.83 Å | A/B=189-505 |
| 2RKZ | X-ray | 2.0 Å | M/N/O/P/Q/R=529-549 |
| 2RL0 | X-ray | 2.0 Å | C/E/G/H/J/L=638-655 |
| 4B5Z | X-ray | 2.2 Å | A=189-505 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.