Interleukin-2 receptor subunit beta (IL2RB) is a 551-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P14784.
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The mean pLDDT of this model is 64.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185)
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6E8K | X-ray | 1.71 Å | B=381-393 |
| 7S2S | X-ray | 1.93 Å | B/D=27-236 |
| 2B5I | X-ray | 2.3 Å | B=27-240 |
| 5M5E | X-ray | 2.3 Å | B=27-240 |
| 4GS7 | X-ray | 2.35 Å | B=27-240 |
| 9KMC | EM | 2.97 Å | B=27-240 |
| 2ERJ | X-ray | 3.0 Å | B/F=27-232 |
| 3QAZ | X-ray | 3.8 Å | B/E/H/K/N/Q/T/W/Z/c/f/i=24-240 |
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