Aminopeptidase N (ANPEP) is a 967-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15144.
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The mean pLDDT of this model is 93.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity)
Homodimer. Interacts with SLC6A19 (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7AEW | X-ray | 1.2 Å | BBB/CCC=36-73 |
| 6XWD | X-ray | 1.6 Å | P=38-46 |
| 4FYT | X-ray | 1.85 Å | A=66-967 |
| 4FYQ | X-ray | 1.9 Å | A=66-967 |
| 4FYR | X-ray | 1.91 Å | A=66-967 |
| 4FYS | X-ray | 2.01 Å | A=66-967 |
| 6U7G | X-ray | 2.35 Å | A/B=66-967 |
| 5LHD | X-ray | 2.6 Å | A/B/C/D=36-967 |
| 6U7F | X-ray | 2.75 Å | A/B=66-967 |
| 9CAM | EM | 2.96 Å | A/B=1-967 |
| 6U7E | X-ray | 3.0 Å | A/B=66-967 |
| 7VPQ | X-ray | 3.1 Å | A/C/E=62-963 |
| 9CAO | EM | 3.14 Å | A/B=1-967 |
| 6ATK | X-ray | 3.5 Å | A/B/C=66-967 |
| 8WDE | EM | 3.6 Å | D/E=66-967 |
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