Cytotoxic T-lymphocyte protein 4 (CTLA4) is a 223-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P16410.
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The mean pLDDT of this model is 80.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)
Homodimer; disulfide-linked (PubMed:11279501, PubMed:11279502, PubMed:21156796, PubMed:28484017, Ref.24). Interacts with ICOSLG (PubMed:28484017)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7CIO | X-ray | 1.1 Å | B=199-206 |
| 9DQ3 | X-ray | 1.64 Å | C=36-153 |
| 3OSK | X-ray | 1.8 Å | A/B=36-161 |
| 5GGV | X-ray | 2.0 Å | Y=36-161 |
| 3BX7 | X-ray | 2.1 Å | C=38-161 |
| 7ELX | X-ray | 2.14 Å | C/c=36-161 |
| 7DV4 | X-ray | 2.38 Å | A/C/E/G=36-153 |
| 7SU0 | X-ray | 2.41 Å | C/D=36-153 |
| 7SU1 | X-ray | 2.53 Å | C=36-153 |
| 2X44 | X-ray | 2.6 Å | D=36-163 |
| 6RP8 | X-ray | 2.6 Å | C/c=37-154 |
| 8GAB | X-ray | 2.72 Å | B/D=36-161 |
| 1I8L | X-ray | 3.0 Å | C/D=36-161 |
| 5TRU | X-ray | 3.0 Å | C/c=37-154 |
| 6RQM | X-ray | 3.0 Å | A=37-161 |
| 6XY2 | X-ray | 3.05 Å | A=38-160 |
| 1I85 | X-ray | 3.2 Å | C/D=36-161 |
| 5XJ3 | X-ray | 3.2 Å | C/F/I/L=36-161 |
| 8HIT | X-ray | 3.2 Å | C=35-154 |
| 6RPJ | X-ray | 3.25 Å | A/C/E/G=37-156 |
Showing 20 of 22 experimental structures (best resolution first).
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