1I85: Ctla-4/B7-2 complex

Crystal structure of the ctla-4/B7-2 complex. Determined by X-ray diffraction at 3.2 Å resolution. Released 4 Apr 2001.

Method: X-ray diffraction
Resolution: 3.2 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,515
Mol. weight: 52.72 kDa
Released: 4 Apr 2001

Explore 1I85 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1I85 contains 0 α-helices and 50 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	1
β-strand	11-13	3	2
β-strand	29-33	5	1
β-strand	39-43	5	1
β-strand	44	1	3
β-strand	47	1	3
β-strand	61-63	3	2
β-strand	70-72	3	2
β-strand	82-88	7	1
β-strand	97-108	12	1

Chain B: 0 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	4
β-strand	11-12	2	5
β-strand	29-33	5	4
β-strand	39-44	6	4
β-strand	47-48	2	4
β-strand	61-64	4	5
β-strand	69-72	4	5
β-strand	82-88	7	4
β-strand	97-108	12	4

Chain C: 0 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	6
β-strand	10-12	3	7
β-strand	19	1	8
β-strand	22-25	4	6
β-strand	34-38	5	9
β-strand	41	1	7
β-strand	46	1	7
β-strand	50-54	5	9
β-strand	59	1	6
β-strand	68	1	8
β-strand	71-72	2	6
β-strand	76-78	3	6
β-strand	81	1	8
β-strand	90-92	3	7
β-strand	94-98	5	9
β-strand	106-107	2	9
β-strand	112-115	4	7

Chain D: 0 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	10
β-strand	10-12	3	11
β-strand	19	1	12
β-strand	22-25	4	10
β-strand	34-38	5	13
β-strand	50-51	2	13
β-strand	54	1	13
β-strand	71-72	2	10
β-strand	76-78	3	10
β-strand	81	1	12
β-strand	90-92	3	11
β-strand	94-98	5	13
β-strand	106-108	3	13
β-strand	112-115	4	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
T lymphocyte activation antigen CD86	A, B	protein	110	Homo sapiens	P42081 (AlphaFold model)
Cytotoxic T-lymphocyte-associated protein 4	C, D	protein	126	Homo sapiens	P16410 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1I85_1 T LYMPHOCYTE ACTIVATION ANTIGEN CD86 (chains A, B)
MLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMG
RTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLA

Sequence of entity 2 (C, D), FASTA

>1I85_2 CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4 (chains C, D)
KAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNEL
TFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPE
PCPDSD

Primary citation

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Schwartz, J.C., Zhang, X., Fedorov, A.A. et al. Nature (2001) 410:604-608. DOI 10.1038/35069112 · PubMed

Other PDB entries of the same protein (UniProt P42081 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5YXK 1.9 Å, High resolution crystal structure of Human B7-2 IgV domain in P21 space group
1NCN 2.7 Å, the receptor-binding domain of human B7-2
8HXB 2.7 Å, Cryo-EM structure of MPXV M2 hexamer in complex with human B7.2
8HXC 3.12 Å, Cryo-EM structure of MPXV M2 heptamer in complex with human B7.2
8FXX 3.26 Å, Cryo-EM structure of cowpox virus M2 in complex with human B7.2 (heptameric ring)
8FXY 3.34 Å, Cryo-EM structure of cowpox virus M2 in complex with human B7.2 (hexameric ring)

Browse structure collections

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