Methylated-DNA--protein-cysteine methyltransferase (MGMT) is a 207-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P16455.
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The mean pLDDT of this model is 85.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1QNT | X-ray | 1.9 Å | A=1-176 |
| 1EH6 | X-ray | 2.0 Å | A=1-207 |
| 1EH7 | X-ray | 2.0 Å | A=1-207 |
| 9QF2 | EM | 2.42 Å | F/G/H/I/J=1-182 |
| 1EH8 | X-ray | 2.5 Å | A=1-207 |
| 9QEY | EM | 2.74 Å | H=1-182 |
| 9QFB | EM | 2.74 Å | H/I/J/K/L/M/N=1-182 |
| 9QFQ | EM | 2.76 Å | P=1-182 |
| 1YFH | X-ray | 3.01 Å | A/B/C=1-179 |
| 9DI0 | EM | 3.1 Å | A=2-178 |
| 9QFE | EM | 3.12 Å | L/M/N=1-182 |
| 9QFW | EM | 3.16 Å | P/Q=1-182 |
| 1T38 | X-ray | 3.2 Å | A=1-176 |
| 1T39 | X-ray | 3.3 Å | A/B=1-176 |
| 8RU2 | EM | 3.49 Å | E/F=1-182 |
| 9QFG | EM | 3.49 Å | J/K/L/M/N=1-182 |
| 8RGH | EM | 3.9 Å | A=2-184 |
| 9QFK | EM | 3.99 Å | H/I/K/L/M/N=1-182 |
| 8RGG | EM | 4.0 Å | B=2-184 |
| 8RTY | EM | 6.25 Å | E/F=2-182 |
Showing 20 of 21 experimental structures (best resolution first).
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