Thyrotropin receptor (TSHR) is a 764-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P16473.
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The mean pLDDT of this model is 74.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase (PubMed:11847099, PubMed:35940205, PubMed:35940204). This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (PubMed:27638195). Additionally, plays a…
Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production (PubMed:12045258). Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function (PubMed:15775968). Interacts with GNAS (PubMed:35940205, PubMed:35940204)
Cell membrane, Basolateral cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2XWT | X-ray | 1.9 Å | C=22-260 |
| 7UTZ | EM | 2.4 Å | R=21-764 |
| 3G04 | X-ray | 2.55 Å | C=22-260 |
| 7XW6 | EM | 2.78 Å | R=21-764 |
| 7T9I | EM | 2.9 Å | R=22-764 |
| 7T9N | EM | 2.9 Å | R=22-764 |
| 7XW5 | EM | 2.96 Å | R=21-764 |
| 7T9M | EM | 3.1 Å | R=22-764 |
| 7XW7 | EM | 5.5 Å | R=21-764 |
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