Vascular endothelial growth factor receptor 1 (FLT1) is a 1338-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P17948.
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The mean pLDDT of this model is 72.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated…
Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR. Interacts (when tyrosine phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably also interacts with PTPRB. Interacts with RACK1. Identified in a complex with CBL and CD2AP
Cell membrane, Endosome, Secreted, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1FLT | X-ray | 1.7 Å | X/Y=132-226 |
| 4CL7 | X-ray | 2.0 Å | A/B/C/D=132-225 |
| 5ABD | X-ray | 2.0 Å | E/I/X=132-226 |
| 4CKV | X-ray | 2.06 Å | X=132-225 |
| 5EX3 | X-ray | 2.41 Å | D=827-835 |
| 1RV6 | X-ray | 2.45 Å | X/Y=130-229 |
| 1QTY | X-ray | 2.7 Å | T/U/X/Y=129-229 |
| 3HNG | X-ray | 2.7 Å | A=801-1158 |
| 2XAC | X-ray | 2.71 Å | C/X=129-226 |
| 5T89 | X-ray | 4.0 Å | X/Y=27-656 |
| 1QSV | NMR | A=129-229 | |
| 1QSZ | NMR | A=129-229 |
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