Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) is a 176-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18509.
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The mean pLDDT of this model is 62.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 38% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (PubMed:11175907, PubMed:23800469, PubMed:32047270, PubMed:32004469, PubMed:36385145). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (PubMed:23800469). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (PubMed:23800469). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8E3X | EM | 2.3 Å | P=132-158 |
| 8E3Y | EM | 2.3 Å | P=132-158 |
| 7VQX | EM | 2.74 Å | L=132-158 |
| 9P94 | EM | 3.0 Å | P=132-158 |
| 6P9Y | EM | 3.01 Å | P=132-169 |
| 6VN7 | EM | 3.2 Å | L=132-158 |
| 7WBJ | EM | 3.42 Å | L=132-158 |
| 6M1I | EM | 3.5 Å | B=132-169 |
| 6LPB | EM | 3.9 Å | P=132-169 |
| 1GEA | NMR | A=132-152 | |
| 2D2P | NMR | A=132-169 | |
| 2JOD | NMR | B=137-169 |
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