Vesicle-fusing ATPase (NSF) is a 744-residue protein from Cricetulus griseus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18708.
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The mean pLDDT of this model is 85.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling
Homohexamer. Interacts with GABARAP and GABARAPL2 (By similarity). Interacts with GRIA2 (By similarity). Interacts with PLK2, leading to disrupt the interaction with GRIA2 (By similarity). Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1D2N | X-ray | 1.75 Å | A=479-743 |
| 1NSF | X-ray | 1.9 Å | A=478-744 |
| 1QCS | X-ray | 1.9 Å | A=1-205 |
| 1QDN | X-ray | 2.3 Å | A/B/C=1-203 |
| 9OJR | EM | 2.95 Å | A/B/C/D/E/F=1-744 |
| 9OJU | EM | 2.97 Å | A/B/C/D/E/F=1-744 |
| 9PFF | EM | 3.09 Å | A/B/C/D/E/F=1-744 |
| 9PFC | EM | 3.15 Å | A/B/C/D/E/F=1-744 |
| 9OK5 | EM | 3.29 Å | A/B/C/D/E/F=1-744 |
| 9OJZ | EM | 3.39 Å | A/B/C/D/E/F=1-744 |
| 9PB9 | EM | 3.45 Å | A/B/C/D/E/F=1-744 |
| 9PBA | EM | 3.47 Å | A/B/C/D/E/F=1-744 |
| 9OLJ | EM | 3.52 Å | A/B/C/D/E/F=1-744 |
| 9OLO | EM | 3.56 Å | A/B/C/D/E/F=1-744 |
| 9PFG | EM | 3.58 Å | J/K=1-744 |
| 9NV9 | EM | 3.6 Å | A/B/C/D/E/F/G=1-744 |
| 9PAG | EM | 3.62 Å | A/B/C/D/E/F=1-744 |
| 9PCZ | EM | 3.65 Å | A/B/C/D/E/F=1-744 |
| 9OKC | EM | 3.67 Å | A/B/C/D/E/F=1-744 |
| 9PC3 | EM | 3.69 Å | A/B/C/D/E/F=1-744 |
Showing 20 of 42 experimental structures (best resolution first).
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