Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) is a 455-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19438.
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The mean pLDDT of this model is 71.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase
Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades,…
Cell membrane, Golgi apparatus membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8P6Q | X-ray | 1.4 Å | A=101-145 |
| 1EXT | X-ray | 1.85 Å | A/B=41-201 |
| 1NCF | X-ray | 2.25 Å | A/B=41-201 |
| 8ZUI | EM | 2.56 Å | D/E/F/J/K/L=30-211 |
| 9V9C | EM | 2.62 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=342-455 |
| 7KP7 | X-ray | 2.65 Å | D/E/F=42-184 |
| 1TNR | X-ray | 2.85 Å | R=44-182 |
| 1FT4 | X-ray | 2.9 Å | A/B=41-201 |
| 7KPB | X-ray | 3.0 Å | E/F=42-184 |
| 7KP8 | X-ray | 3.15 Å | E/F=43-184 |
| 9VIN | EM | 3.41 Å | A/B/C/D/G/a/b/c/d/e/f/g/h=342-455 |
| 1ICH | NMR | A=345-455 | |
| 7K7A | NMR | A/B/C=209-238 |
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