Glutamate receptor 3 (Gria3) is a 888-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19492.
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The mean pLDDT of this model is 83.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1699567, PubMed:1709304, PubMed:2166337, PubMed:2168579). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an…
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (PubMed:21317871). Tetramers may be formed by the dimerization of dimers (PubMed:21317871). Interacts with PICK1, GRIP1 and GRIP2 (PubMed:10027300, PubMed:10414981, PubMed:9069286). Found in a complex with GRIA1, GRIA2, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (PubMed:19265014). Interacts…
Cell membrane, Postsynaptic cell membrane, Postsynaptic density membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3LSW | X-ray | 1.75 Å | A=417-530 |
| 4F29 | X-ray | 1.75 Å | A=417-530, A=658-799 |
| 3M3K | X-ray | 1.79 Å | A/C/E=417-530, A/C/E=658-799 |
| 4F1Y | X-ray | 1.79 Å | A/C=417-530, A/C=658-799 |
| 4F3B | X-ray | 1.82 Å | A=417-530, A=658-799 |
| 4F39 | X-ray | 1.83 Å | A=417-530, A=658-799 |
| 3DLN | X-ray | 1.91 Å | A=416-530, A=658-799 |
| 4F2O | X-ray | 1.91 Å | A=417-530, A=658-799 |
| 6FPJ | X-ray | 1.96 Å | A/B/C=23-403 |
| 3LSX | X-ray | 2.01 Å | A=417-530, A=658-769 |
| 4F22 | X-ray | 2.06 Å | A=417-530, A=658-799 |
| 4F3G | X-ray | 2.06 Å | A=417-530, A=658-799 |
| 3DP4 | X-ray | 2.11 Å | A=416-530, A=658-799 |
| 5FWY | X-ray | 2.12 Å | B/D=23-403 |
| 3O21 | X-ray | 2.2 Å | A/B/C/D=23-403 |
| 4F2Q | X-ray | 2.2 Å | A=417-530, A=658-799 |
| 4F31 | X-ray | 2.29 Å | B/D=417-530, B/D=658-799 |
| 3RT8 | X-ray | 2.43 Å | A=417-530, A=658-799 |
| 3M3F | X-ray | 2.5 Å | A=417-530, A=658-799 |
| 6FLR | X-ray | 2.51 Å | A/B=23-403 |
Showing 20 of 33 experimental structures (best resolution first).
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