Circumsporozoite protein (CSP) is a 397-residue protein from Plasmodium falciparum (isolate NF54). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19597.
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The mean pLDDT of this model is 54.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 2% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Essential sporozoite protein (PubMed:32451496). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:32451496). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity)
Cell membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6O24 | X-ray | 1.4 Å | I=261-272 |
| 6VLN | X-ray | 1.63 Å | P=117-128 |
| 8FB8 | X-ray | 1.69 Å | P=95-109 |
| 6ULF | X-ray | 1.7 Å | P=193-204 |
| 6O26 | X-ray | 1.8 Å | C=289-302 |
| 8FA7 | X-ray | 1.8 Å | P=95-109 |
| 8FDC | X-ray | 1.8 Å | P=95-109 |
| 6O28 | X-ray | 1.93 Å | E/F=95-109 |
| 6B0S | X-ray | 1.95 Å | C=310-374 |
| 6O23 | X-ray | 2.0 Å | E=253-272 |
| 6O2C | X-ray | 2.02 Å | C=261-272 |
| 9HZJ | X-ray | 2.06 Å | B=310-384 |
| 9HZK | X-ray | 2.07 Å | B=310-384 |
| 6O2B | X-ray | 2.1 Å | F/G/K/L=117-128 |
| 6O2A | X-ray | 2.15 Å | F/G/K/L=193-204 |
| 8FB6 | X-ray | 2.15 Å | P=95-109 |
| 8F9V | X-ray | 2.25 Å | M/N/O/P=95-109 |
| 6O29 | X-ray | 2.4 Å | C/D=101-116 |
| 6ULE | X-ray | 2.55 Å | I=253-272 |
| 6O25 | X-ray | 2.9 Å | D/H/L=261-272 |
Showing 20 of 24 experimental structures (best resolution first).
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