3MCB: PDB entry 3MCB

Crystal structure of NAC domains of human nascent polypeptide-associated complex (NAC). Determined by X-ray diffraction at 1.9 Å resolution. Released 14 Jul 2010.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: Homo sapiens
Chains: 2
Atoms: 928
Mol. weight: 12.72 kDa
Released: 14 Jul 2010

Explore 3MCB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3MCB contains 4 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	80-83	4
α-helix	85	1
β-strand	86-87	2	1
β-strand	91-97	7	2
β-strand	102-106	5	2
β-strand	110-113	4	1
β-strand	119-123	5	1
β-strand	126-130	5	2

Chain B: 2 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	55-56	2	1
β-strand	61-66	6	2
β-strand	70-75	6	2
β-strand	78-82	5	1
β-strand	87-91	5	1
β-strand	94-98	5	2
α-helix	99-102	4
α-helix	105-109	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Nascent polypeptide-associated complex subunit alpha	A	protein	54	Homo sapiens	Q13765 (AlphaFold model)
Transcription factor BTF3	B	protein	58	Homo sapiens	P20290 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3MCB_1 Nascent polypeptide-associated complex subunit alpha (chains A)
AMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLS

Sequence of entity 2 (B), FASTA

>3MCB_2 Transcription factor BTF3 (chains B)
VNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQL

Primary citation

Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit. Wang, L.F., Zhang, W.C., Wang, L. et al. Protein Cell (2010) 1:406-416. DOI 10.1007/s13238-010-0049-3 · PubMed

Other PDB entries of the same protein (UniProt Q13765 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
9S3D 2.32 Å, NAC bound human RNC with 58 amino acid ARF1-linker
9S3B 2.38 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 1
3MCE 2.4 Å, Crystal structure of the NAC domain of alpha subunit of nascent polypeptide-associated…
9S3C 2.42 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 2
9QLO 2.47 Å, NMT1-NAC bound human RNC with full length ARF1 - State 1
3LKX 2.5 Å, Human nac dimerization domain
9QLQ 2.57 Å, NMT1-NAC bound human RNC with full length ARF1 - alternative State
9MR4 2.65 Å, NAC: Ribosome nascent chain complex(Oxa1L)
9T6D 2.67 Å, NAA40-NAC bound human 80S (combined translation states)
28LN 2.7 Å, XBP1u-stalled RPL4 RNC in complex with NAC
9RG7 2.72 Å, In vitro reconstituted NAA40-NAC bound 80S

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